Acute and chronic effects, including overdose, from the use of

Framing

  • Acute intoxication, chronic use effects, and overdose toxicity differ substantially by substance class - alcohol, amphetamines, benzodiazepines/Z-drugs, cannabis, cocaine, ecstasy (MDMA), and opioids each have a distinct receptor mechanism, intoxication syndrome, overdose danger, and withdrawal profile
  • Recognising the specific substance-associated pattern (from history, examination, and toxidrome recognition) directly guides both acute management and harm-reduction/withdrawal planning

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