Adverse drug reactions from

Framing

  • Adverse drug reactions have characteristic patterns by drug class - antiarrhythmics (pro-arrhythmic paradox), antibiotics (allergic and idiosyncratic reactions), anticoagulants (bleeding), anticonvulsants (idiosyncratic hypersensitivity, teratogenicity), antidepressants (serotonin syndrome, discontinuation syndrome), chemotherapy (organ-specific toxicity), and NSAIDs (GI, renal, cardiovascular) - recognising the class-specific pattern speeds diagnosis when a patient on one of these agents presents unwell
  • See for the structured causality assessment approach (Naranjo scale) applied once a reaction is suspected

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