Adverse drug reactions from - antiarrhythmics
Reaction patterns by class
- Most antiarrhythmics are proarrhythmic - the reaction they cause is often the same class of problem they treat
- Class-specific patterns
- Amiodarone: multi-organ toxicity (thyroid, lung, liver, cornea, skin) - the classic "everything drug"
- Flecainide (Class Ic): proarrhythmia in structural/ischaemic heart disease - contraindicated
- Sotalol: QT prolongation -> torsades (beta-blocker + Class III combined effect)
- Digoxin: see poisoning-from-digoxin
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