Immunology and AllergyTier 1Topic overview

Allergic disorders

Framing

  • Allergic disorders span IgE-mediated immediate hypersensitivity (anaphylaxis, allergic rhinitis, food allergy) and mixed/local mucosal hypersensitivity (eosinophilic oesophagitis, allergic conjunctivitis, sinusitis) - all sharing a Th2-driven inflammatory mechanism but differing in target organ and severity, from mild rhinitis to life-threatening anaphylaxis
  • Anaphylaxis is the unifying emergency across this group - recognising when a presentation has crossed from a localised allergic reaction into systemic anaphylaxis (airway, breathing, or circulation compromise) is the single most safety-critical skill in this topic

What sits under this topic

  • See for the systemic emergency and adrenaline-first management
  • See and for common IgE-mediated presentations
  • See , , and for organ-specific atopic disease
  • See for a mixed IgE/non-IgE oesophageal presentation
  • See for drug-triggered allergic and pseudo-allergic reactions

2 of 2 sections written · drafted 2026-09-14