RheumatologyTier 1Topic overview

Arthritis

Framing

  • Rheumatological arthritis classification separates inflammatory (rheumatoid arthritis, seronegative spondyloarthropathies), crystal-associated (gout, pseudogout), degenerative (osteoarthritis), and infective (septic arthritis) causes - each with a distinct joint fluid/serological signature and treatment approach, making synovial fluid analysis (when a joint effusion is present) one of the highest-yield investigations across this whole topic
  • Acute monoarthritis always requires excluding septic arthritis as the first priority, since missed joint sepsis causes rapid, irreversible cartilage destruction

What sits under this topic

  • See for the acute presentation and initial diagnostic approach
  • See for the prototypical inflammatory polyarthritis
  • See for crystal arthropathy
  • See for degenerative joint disease
  • See for the joint sepsis emergency
  • See for the HLA-B27-associated inflammatory arthritis group

2 of 2 sections written · drafted 2026-09-14