Calcium channel blocker and beta blocker overdose
Description
- Two distinct drug classes converging on a similar clinical picture: bradycardia + hypotension + cardiogenic shock, via different final pathways
- CCBs, especially non-dihydropyridines (verapamil, diltiazem) - block L-type Ca2+ channels in myocardium/vasculature -> negative inotropy, chronotropy, dromotropy + vasodilation
- Beta-blockers - block myocardial beta-1 receptors -> negative inotropy/chronotropy; loss of catecholamine-driven compensation
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