PhysiologyTier 2Medical Sciences concept

ECG changes in electrolyte disturbance (U waves-hypokalaemia, peaked T-hyperkalaemia)

Core concept

  • Potassium sets the resting membrane potential; calcium sets the plateau (phase 2) duration
    • -> K+ abnormalities change the T wave, QRS and P wave. Ca2+ abnormalities change the ST segment and QT interval, with a normal T wave.
  • Hyperkalaemia - inc extracellular K+ -> less negative resting potential -> Na channel inactivation
    • -> slowed conduction (wide QRS), and faster repolarisation (tall narrow T)
  • Hypokalaemia - hyperpolarised, prolonged repolarisation -> ST depression, flat T, U wave
  • Hypocalcaemia - prolonged phase 2 -> long ST segment -> long QT with a normal-width T wave
  • Hypercalcaemia - short ST -> short QT

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