Emerging or less common infections
Framing
- CMV and toxoplasmosis are both ubiquitous organisms causing mild/subclinical infection in immunocompetent hosts but significant disease in two specific vulnerable groups - the immunocompromised (reactivation disease) and the developing fetus (congenital infection from primary maternal infection) - making risk-group-specific screening and prophylaxis the shared management principle across both
- Despite the "emerging" framing, both organisms are highly prevalent globally - the clinical challenge is not rarity but recognising when reactivation/primary infection in a vulnerable host requires active intervention
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