Emicizumab mechanism (bispecific factor IXa/X antibody mimicking factor VIII)
Core concept
- Bispecific monoclonal antibody - one arm binds activated factor IXa, the other binds factor X - bridges them on the phospholipid surface, mimicking the cofactor function of factor VIII
- Restores intrinsic tenase complex (IXa-VIIIa-X) function without being factor VIII itself - not neutralised by factor VIII inhibitors
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