Thyroid disease, such as thyroid malignancy
Description
Follicular cell-derived
| Share | Spread | Key point | |
|---|---|---|---|
| Papillary (PTC) | ~85% | Lymphatic | Best prognosis; radiation-associated |
| Follicular (FTC) | ~10% | Haematogenous (bone, lung) | FNA cannot diagnose - capsular/vascular invasion needs histology |
| Oncocytic (Hurthle) | ~3% | Both | Less iodine-avid |
| Anaplastic (ATC) | 1-2% | Local + distant | Median survival months |
C-cell derived
- Medullary (MTC) ~3% - calcitonin-secreting, not iodine-avid, thyroglobulin useless
- 25% hereditary (MEN2A, MEN2B, familial MTC)
- Thyroid lymphoma - rare; arises in a Hashimoto gland, rapidly enlarging
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