NeurologyTier 1Disease (DEADMAN)

Essential tremor

Description

  • Isolated bilateral action tremor of the upper limbs, present for >=3 years, without other neurological signs
  • Action tremor = postural (arms outstretched) + kinetic (finger-nose, pouring, drawing spiral)
    • 4-12 Hz, typically 6-8 Hz
  • Essential tremor plus - the same tremor with soft additional signs (impaired tandem gait, questionable dystonic posturing, mild memory impairment, rest tremor)
Distribution
  • Hands ~95% (bilateral, may be mildly asymmetric)
  • Head ~30-40% ("no-no" or "yes-yes") - far more common than in Parkinson disease
  • Voice ~20% - quavering, worse on sustained vowel
  • Legs, trunk, jaw less common
Essential tremor vs Parkinson disease - the core discrimination
Essential tremorParkinson disease
Tremor typePostural + kineticRest ('pill-rolling'), re-emergent on posture
Frequency6-12 Hz4-6 Hz
SymmetryBilateral, roughly symmetricAsymmetric
Head tremorCommonRare (jaw and chin instead)
HandwritingLarge, tremulousMicrographia
Effect of alcoholImprovesNo effect
Family history~50-70%~15%
Other signsNoneBradykinesia, rigidity, hypomimia, hyposmia, RBD
CourseSlowly progressive over decadesProgressive over years
LevodopaNo responseResponds
  • *Bradykinesia is what makes it Parkinson disease* - test repetitive finger tapping for decrement in amplitude, not just speed

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