Fanconi syndrome - causes (drugs, genetic, paraprotein)
Core concept
- Generalised proximal tubular failure - everything the PCT reabsorbs is spilled
| Lost in urine | Serum consequence |
|---|---|
| Glucose - with a normal BSL | the giveaway on dipstick |
| Phosphate | Hypophosphataemia |
| Urate | Hypouricaemia |
| Bicarbonate | Type 2 (proximal) RTA, hypokalaemia |
| Amino acids | Aminoaciduria |
| LMW proteins (beta-2 microglobulin, RBP) | Tubular proteinuria |
| Sodium, water, calcium | Polyuria, hypercalciuria |
- Chronic phosphate wasting -> osteomalacia in adults, rickets in children, proximal myopathy
- Fanconi syndrome is not Fanconi anaemia - unrelated conditions, different Fanconi
3 more sections, plus exam facts
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