PhysiologyTier 1Medical Sciences concept

Flow-volume loop interpretation (fixed vs variable, intrathoracic vs extrathoracic obstruction)

Core concept

  • Expiration above the axis, inspiration below; volume on the x-axis (TLC at left, RV at right)
  • Only the first ~1 second (to peak expiratory flow) is effort-dependent
    • The rest of the expiratory limb is effort-independent, limited by dynamic airway compression at the equal pressure point
    • -> a patient cannot fake a normal descending limb, but can fake a low PEF
  • The inspiratory limb is effort-dependent throughout - negative intrathoracic pressure holds intrathoracic airways open
  • -> The pressure gradient across the lesion during each phase determines which limb flattens

3 more sections, plus exam facts

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