Growth hormone axis regulation
Core concept
- Hypothalamus: GHRH (stimulates) vs somatostatin (inhibits) -> anterior pituitary GH -> acts directly AND via IGF-1 (mainly hepatic)
- GH has direct metabolic effects (lipolysis, anti-insulin/diabetogenic, protein synthesis) and indirect growth-promoting effects mediated by IGF-1
- Negative feedback: IGF-1 inhibits both GHRH and GH (long loop); GH itself stimulates somatostatin (short loop)
3 more sections, plus exam facts
Premium unlocks every note across every specialty, and the full exam fact library behind it.
Get premium access