Haematological malignancies
Framing
- Haematological malignancies arise from clonal proliferation at any stage of myeloid or lymphoid differentiation, broadly grouped into leukaemias (predominantly blood/marrow), lymphomas (predominantly nodal/extranodal lymphoid tissue), myeloproliferative neoplasms, myelodysplasia, and plasma cell dyscrasias
- Classification by lineage and maturation stage directly predicts clinical behaviour and treatment intent - acute leukaemias and aggressive lymphomas require urgent, intensive treatment, while chronic/indolent entities are often managed expectantly with risk-adapted therapy
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