Haematological malignancies - leukaemia, acute and chronic
Framing
- Leukaemia is classified along two axes - acute vs chronic (blast-predominant, rapidly progressive disease vs a more indolent clonal proliferation) and lymphoid vs myeloid (cell lineage of origin) - producing four principal categories, each with a distinct age distribution, presentation, and treatment approach
- This classification directly predicts urgency: acute leukaemias require prompt treatment given rapid marrow failure, while chronic leukaemias are often managed expectantly or with risk-stratified, non-curative-intent therapy
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