Haematological malignancies - myeloproliferative disease
Framing
- Myeloproliferative neoplasms arise from clonal, JAK2/CALR/MPL-driven overproduction of one or more mature myeloid lineages - distinguished from leukaemia by preserved (indeed excessive) terminal differentiation rather than a maturation block
- Shared thrombosis risk (arterial and venous) across the group drives much of the management approach, alongside the distinct risk of transformation to acute myeloid leukaemia or myelofibrosis over time
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