Framing
- Transfusion reactions span immune-mediated (haemolytic - acute/delayed, febrile non-haemolytic, allergic/anaphylactic) and non-immune (circulatory overload, transfusion-related acute lung injury) mechanisms - accurate classification of a reaction during/after transfusion determines whether the transfusion should be stopped immediately, and guides subsequent product selection
- Acute haemolytic reactions (ABO incompatibility) are the most immediately dangerous and are preventable through correct patient/product verification, making this a key patient-safety checkpoint
What sits under this topic
- See for ABO-incompatibility-driven acute intravascular haemolysis
- See for anamnestic alloantibody-mediated delayed haemolysis
- See for the most common, generally benign reaction type
- See for IgE-mediated and severe anaphylactic reactions
- See and for the two major non-immune pulmonary complications
- See for an overall comparison of reaction types and relative frequency
2 of 2 sections written · drafted 2026-09-14