Laboratory investigations - autoantibody markers of autoimmune neurological disease

Overview

  • Antinuclear antibody (ANA) testing screens for a broad range of autoantibodies targeting nuclear antigens - the standard first-line screen when systemic autoimmune disease is suspected
  • ANA positivity is common in the general population (up to ~15-20% at low titre) and rises with age - a positive result alone is not diagnostic of anything

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