Laboratory tests - coeliac serology

The tests

Coeliac serology - tissue transglutaminase IgA (tTG-IgA) as the standard first-line test - screens for coeliac disease with high sensitivity/specificity, but must always be interpreted alongside total IgA level given the risk of false-negative results in IgA deficiency
Coeliac disease affects roughly 1% of the population, with testing increasingly used both for symptomatic patients and for at-risk screening (first-degree relatives, associated autoimmune conditions)

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