PhysiologyTier 1Medical Sciences concept

Lesion localisation in the nervous system

Core concept

  • Neurological signs localise to a specific level -- match the pattern to a single anatomical site before considering aetiology
  • Cortex: contralateral weakness/sensory loss face+arm>leg (MCA) or leg>arm (ACA); cortical signs (aphasia, neglect, apraxia)
  • Subcortical/internal capsule (lacunar): pure motor or pure sensory deficit, no cortical signs (no aphasia/neglect) -- small vessel disease
  • Brainstem: crossed signs (ipsilateral cranial nerve + contralateral limb) -- localises the side and level precisely
  • Spinal cord: bilateral, sensory level, sphincter involvement

3 more sections, plus exam facts

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