Neurodegenerative disease classification by protein aggregate (synucleinopathies vs tauopathies)
Core concept
- Neurodegenerative disease classified by the misfolded protein that aggregates, not by clinical syndrome alone
- Synucleinopathies - alpha-synuclein aggregates (Lewy bodies/neurites, or glial cytoplasmic inclusions)
- Parkinson's disease, Dementia with Lewy Bodies, Multiple System Atrophy
- Tauopathies - hyperphosphorylated tau aggregates
- Alzheimer's disease (+ amyloid-beta plaques), Progressive Supranuclear Palsy, Corticobasal degeneration, frontotemporal dementia (tau subtype)
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