Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy (CIDP)
Framing
- Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) are both immune-mediated demyelinating polyradiculoneuropathies, distinguished chiefly by time course - GBS is monophasic, peaking within 4 weeks (often post-infectious), while CIDP is chronic/relapsing, progressing or relapsing over more than 8 weeks
- This time-course distinction has direct treatment implications - GBS is treated with a single course of IVIG or plasma exchange, while CIDP typically requires longer-term or maintenance immunotherapy given its chronic/relapsing course
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