PhysiologyTier 1Medical Sciences concept

Physiological adaptations of pregnancy (cardiovascular, haematological, respiratory)

Core concept

  • The organising principle: a volume-loaded, vasodilated, hypercoagulable, alkalotic state
    • Progesterone -> systemic vasodilatation; relaxin -> renal vasodilatation
    • -> dec SVR -> underfilling -> RAAS activation -> Na and water retention -> plasma volume expansion

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