Principles of pharmacology and pharmacokinetics

Framing

Pharmacokinetics (what the body does to a drug) spans absorption, distribution/bioavailability, metabolism, and excretion (ADME) - each step affecting how much active drug reaches its target and for how long, and each being a point where disease states, drug interactions, and genetic variation can alter drug exposure
Understanding each ADME step underpins rational dosing, interaction prediction, and dose adjustment in organ impairment across all of clinical pharmacology

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