Reduction in cell counts
Framing
- Reduced blood cell counts (any lineage) reflect either reduced production (marrow failure, infiltration, nutritional deficiency) or increased destruction/loss (haemolysis, sequestration, consumption) - this mechanistic fork structures the entire diagnostic approach for any cytopenia
- Multi-lineage cytopenia (affecting two or more lineages simultaneously) raises the threshold of concern for a primary marrow process (myelodysplasia, infiltrative malignancy, aplastic anaemia) over an isolated single-lineage cause
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