General MedicineTier 1Approach to a presentation

Undifferentiated presentations - fatigue

Red flags

  • Fatigue + weight loss + night sweats - malignancy/lymphoma/TB
  • Fatigue + pallor + bleeding - haematological malignancy/bone marrow failure
  • Fatigue + focal neurology - consider demyelination, stroke
  • Fatigue + chest pain/dyspnoea - cardiac cause (may be anginal equivalent, esp. in women/diabetics)
  • Profound fatigue with postural symptoms - Addisonian crisis, severe anaemia

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